There are a few routes Best Airline to Fly to Spain and service while looking for the best airline to fly to Spain. The flag carrier of Spain, Iberia, provides genuine Spanish onboard service on direct flights to important destinations like Madrid and Barcelona. Excellent options are also offered from the United States by American Airlines and Delta, which have competitive prices and good in-flight amenities. Low-cost airlines like Ryanair and Vueling are great for travelers on a tight budget because they offer reasonable fares to a variety of Spanish destinations. The ideal option will ultimately depend on elements like the desired amenities, budget, and departure city, guaranteeing a customized trip to Spain.